Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis
Marta Varela-Eirín, Paula Carpintero-Fernández, Agustín Sánchez‐Temprano, Adrián Varela-Vázquez, Carlos Luis Paı́no, Antonio Casado‐Díaz, Alfonso Calañas Continente, Virginia Mato‐Abad, Eduardo Fonseca, Mustapha Kandouz, Alfonso Blanco, José Ramón Caeiro, María D. Mayán
Abstract
results demonstrate the use of olive-derived polyphenols, such as oleuropein, as potentially effective therapeutic agents to improve chondrogenesis of hMSCs, to induce chondrocyte re-differentiation in OACs and clearing out senescent cells in joint tissues in order to prevent or stop the progression of the disease.
Topics & Concepts
OleuropeinChondrogenesisChondrocyteOsteoarthritisCartilageCell biologyRegeneration (biology)ChemistryMesenchymal stem cellCancer researchMedicineBiologyPathologyAnatomyBiochemistryAntioxidantAlternative medicineConnexins and lens biologySkin Protection and AgingFatty Acid Research and Health