Dual Inhibition of B7-H3 and EGFR Overcomes Acquired Chemoresistance in Colon Adenocarcinoma
Liang-Chi Chen, Pei-Chen Yang, Chia-Yi Chen, Shu‐Fen Chiang, Tsung-Wei Chen, William Tzu‐Liang Chen, Tao‐Wei Ke, Ji‐An Liang, An‐Cheng Shiau, K. S. Clifford Chao, Kevin Chih‐Yang Huang
Abstract
. Overall, these results showed that B7-H3 exhibited a high prevalence in COAD patients and was significantly associated with worse prognosis in COAD patients. Dual targeting of B7-H3 and EGFR signaling might be a potential therapeutic strategy for high-risk COAD patients.
Topics & Concepts
MedicineColorectal cancerOxaliplatinOncologyInternal medicineImmunotherapyChemotherapyCancer researchAdenocarcinomaMetastasisCancerCancer Immunotherapy and BiomarkersColorectal and Anal CarcinomasColorectal Cancer Treatments and Studies