Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca<sup>2+</sup>-dependent endoplasmic reticulum stress in VSMCs
Ruli Li, Caili Zhuo, Xin Yan, He Li, Lan Lin, Lingyu Li, Qiying Jiang, Die Zhang, Xuemei Wang, Lin-ling Liu, Wenjing Huang, Ying-ling Wang, Xinyue Li, Yan Mao, Yixin Chen, Xiao Liu, Quanchen Xu, Yu-yan Cai, Xijing Yang, Hongying Chen, Sisi Wu, Wei Jiang
Abstract
-dependent ER stress. Furthermore, irisin was confirmed to bind to its receptors, αV/β5 integrins, to further activate the AMPK pathway and inhibit the p38 pathway, leading to vasoprotection in Ang II-insulted VSMCs. These results indicate that irisin protects against hypertension and vascular remodeling in Ang II-challenged mice by restoring calcium homeostasis and attenuating ER stress in VSMCs via activating AMPK and suppressing p38 signaling.
Topics & Concepts
FNDC5EndocrinologyInternal medicineEndoplasmic reticulumAngiotensin IIVascular smooth muscleUnfolded protein responseMyokineHomeostasisReceptorMedicineChemistryCell biologyBiologyExtracellular matrixSkeletal muscleFibronectinSmooth muscleAdipose Tissue and MetabolismEicosanoids and Hypertension PharmacologyMitochondrial Function and Pathology