Discovery of (R)-4-(8-methoxy-2-methyl-1-(1-phenylethy)-1H-imidazo[4,5-c]quinnolin-7-yl)-3,5-dimethylisoxazole as a potent and selective BET inhibitor for treatment of acute myeloid leukemia (AML) guided by FEP calculation
Su Yu, Yan Zhang, Jie Yang, Hongrui Xu, Suke Lan, Binyan Zhao, Meng Luo, Xinyu Ma, Hongjia Zhang, Shirui Wang, Hui Shen, Yan Zhang, Yong Xu, Rui Li, Rui Li
Topics & Concepts
ChemistryBromodomainIn vivoStereochemistryCell cycle checkpointApoptosisBET inhibitorCell growthCell cycleBiochemistryAcetylationGeneBiologyBiotechnologyProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsHistone Deacetylase Inhibitors Research