Study of Carbamoyl Fluoride: Synthesis, Properties and Applications
Clémence Bonnefoy, Emmanuel Chefdeville, Christian Tourvieille, Armen Panossian, Gilles Hanquet, Frédéric R. Leroux, Fabien Toulgoat, Thierry Billard
Abstract
Abstract Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride is presented. Stability studies, in particular under physiological conditions, and lipophilicity measurement were performed. A new easy, safe, inexpensive, and metal‐free synthesis method is also described. Finally, a potential use in radiochemistry through a 18 F/ 19 F isotopic exchange is demonstrated.
Topics & Concepts
FluorideLipophilicityChemistryCombinatorial chemistryRadiochemistryOrganic chemistryInorganic chemistryFluorine in Organic ChemistryPer- and polyfluoroalkyl substances researchInorganic Fluorides and Related Compounds