Recent Advances in Biomaterial Scaffolds for Integrative Tumor Therapy and Bone Regeneration
Ziyan Huang, Zhengfang Tian, Min Zhu, Chengtie Wu, Yufang Zhu
Abstract
Abstract Bone tumors bring great pain to patients, along with a high disability rate and high mortality. Several therapeutic strategies have been applied to treat bone tumors, such as chemotherapy, radiotherapy, and surgical resection. However, these strategies have intrinsic drawbacks, such as the serious side effects of chemotherapy or the necessary reconstructive surgery of surgical resection. To help develop more satisfactory bone tumor treatment strategies, biomaterial scaffolds have been proposed. Biomaterial scaffolds are often applied for repairing bone defects after surgical resection due to their biocompatibility, osteoinductivity, and osteoconductivity as well as excellent physicochemical properties. Simultaneously, the function of bone tumor therapy offers biomaterial scaffolds to eliminate residual tumor cells, thus avoiding tumor recurrence. This review summarizes recent advances in biomaterial scaffolds which are combined with chemotherapy or hyperthermia therapy for treating bone tumors and further bone regeneration. Moreover, the progress in synergistic therapy of bone tumors based on biomaterial scaffolds is also discussed. This review aims to inspire researchers to develop novel fabrication or functionalization strategies for constructing multifunctional biomaterial scaffolds with anti‐tumor properties.