Bioinspired Total Synthesis of Hyperireflexolides A and B
Andreas B. zur Bonsen, Christopher J. Sumby, Jonathan H. George
Abstract
Hyperireflexolides A and B were synthesized in six steps via the dearomatization and fragmentation of a simple acylphloroglucinol starting material. The dearomatized acylphloroglucinol undergoes a sequence of oxidative radical cyclization, retro-Dieckmann fragmentation, stereodivergent intramolecular carbonyl-ene reactions, and final α-hydroxy-β-diketone rearrangements to give the target natural products. This sequence is based on a biosynthetic proposal that claims the hyperireflexolides as highly rearranged polycyclic polyprenylated acylphloroglucinols (PPAPs), which is supported by the structural revision of hyperireflexolide B.
Topics & Concepts
ChemistryIntramolecular forceStereochemistryFragmentation (computing)Sequence (biology)Total synthesisBiochemistryOperating systemComputer scienceNatural Compound Pharmacology StudiesBiological Activity of Diterpenoids and BiflavonoidsBioactive natural compounds