Allosteric signaling in C-linker and cyclic nucleotide-binding domain of HCN2 channels
Christopher Pfleger, Jana Kusch, Mahesh Kondapuram, Tina Schwabe, Christian Sattler, Klaus Benndorf, Holger Gohlke
Topics & Concepts
Allosteric regulationChemistryBiophysicsCyclic nucleotide-binding domainCooperativityLinkerHCN channelNucleotideCyclic nucleotideCooperative bindingBinding siteIon channelCyclic nucleotide-gated ion channelStereochemistryBiochemistryCrystallographyReceptorBiologyGeneOperating systemComputer scienceIon channel regulation and functionNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling