Photoredox Catalyzed Thioformylation of Terminal Alkynes Using Nitromethane as a Formyl Source
Muneer‐ul‐Shafi Bhat, Majid Ahmad Ganie, Masood Ahmad Rizvi, Shabnam Raheem, Bhahwal Ali Shah
Abstract
A photoredox thioformylation of terminal alkynes using nitromethane as a formyl anion equivalent, thereby leading to the synthesis of (E)-1,2-difunctionalized acrylaldehyde, has been described. The current strategy introduces an adaptable aldehyde function across an alkyne and offers a new route to synthesizing α-alkyl/aryl aldehydes.
Topics & Concepts
NitromethaneChemistryAldehydeAlkyneArylTerminal (telecommunication)CatalysisAlkylCombinatorial chemistryOrganic chemistryComputer scienceTelecommunicationsSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods