Heparan sulfate promotes differentiation of white adipocytes to maintain insulin sensitivity and glucose homeostasis
Takuro Matsuzawa, Masanobu Morita, Ai Shimane, Rina Otsuka, Mei Yu, Fumitoshi Irie, Yu Yamaguchi, Kazuhiko Yanai, Takeo Yoshikawa
Abstract
mice showed glucose intolerance because of insulin resistance. Our results demonstrate that HS plays a crucial role in the differentiation of white adipocytes through BMP4-FGF1 signaling pathways, thereby contributing to insulin sensitivity and glucose homeostasis.
Topics & Concepts
Glucose homeostasisAdipocyteWhite adipose tissueBiologyAdipose tissueFibroblast growth factorEndocrinologyInternal medicineInsulin resistanceHeparan sulfateInsulin-degrading enzymeInsulinCell biologyBiochemistryReceptorMedicineCellProteoglycans and glycosaminoglycans researchFibroblast Growth Factor ResearchConnective tissue disorders research