Ln<sup>3+</sup>-doped nanoparticles with enhanced NIR-II luminescence for lighting up blood vessels in mice
Cong Cao, Na Wu, Wei Yuan, Yuyang Gu, Jiaming Ke, Wei Feng, Fuyou Li
Abstract
at 1530 nm increased 10 times, while the upconversion luminescence decreased to less than 1%. After being modified with polyacrylic acid and polyethylene glycol, the as-obtained water-soluble probe exhibits continuous high-resolution for distinguishing 0.25 mm blood vessels even 10 h after injection. Noteworthily, the imaging of tumors was achieved by injecting the probe, indicating that the designed NIR-II probe has sufficient brightness and the ability to passively target tumor tissue.
Topics & Concepts
LuminescenceFluorescenceNanoparticleLuminescent MeasurementsDopingMaterials scienceFluorescence-lifetime imaging microscopyPEG ratioPhotochemistryNuclear chemistryAnalytical Chemistry (journal)NanotechnologyChemistryOptoelectronicsOpticsChromatographyEconomicsPhysicsFinanceLuminescence Properties of Advanced MaterialsNanoplatforms for cancer theranosticsLuminescence and Fluorescent Materials