Translatomic analysis of regenerating and degenerating spinal motor neurons in injury and ALS
Jennifer L. Shadrach, Wesley M. Stansberry, Allison M. Milen, Rachel E. Ives, Elizabeth A. Fogarty, Anthony Antonellis, Brian A. Pierchala
Abstract
A translatomic method evaluated motor neuron gene expression after injury and in ALS This approach highlighted shared and divergent pathways during injury and degeneration Motor neurons upregulate chemokines during axon regeneration and ALS degeneration
Topics & Concepts
NeuroscienceMotor neuronAmyotrophic lateral sclerosisDownregulation and upregulationNerve injuryMedicineBiologySpinal cordPathologyDiseaseBiochemistryGeneAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchNerve injury and regeneration