Cp*Co(<scp>iii</scp>)-catalyzed C–H amination/annulation cascade of sulfoxonium ylides with anthranils for the synthesis of indoloindolones
Yogesh N. Aher, Amit B. Pawar
Abstract
Cp*Co(iii)-catalyzed [4+1] annulation of sulfoxonium ylides with anthranils has been developed for the synthesis of indole-indolone scaffolds. The dual functionality of anthranils was exploited, wherein the nitrogen has been used for C-H amination and the aldehyde group was utilized in the subsequent intramolecular aldol condensation to furnish the corresponding annulated products.
Topics & Concepts
AnnulationAminationCascadeCatalysisChemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms