Usp11 controls cortical neurogenesis and neuronal migration through Sox11 stabilization
Shang-Yin Chiang, Hsin-Chieh Wu, Shu‐Yu Lin, Hsin‐Yi Chen, Chia-Fang Wang, Nai-Hsing Yeh, Jou‐Ho Shih, Yi‐Shuian Huang, Hung‐Chih Kuo, Shen‐Ju Chou, Ruey‐Hwa Chen
Abstract
mRNA. The disease-associated Usp11 mutant fails to stabilize Sox11 and is unable to support cortical neurogenesis and neuronal migration. Our findings define a critical function of Usp11 in cortical development and highlight the importance of orchestrating protein stabilization mechanisms into transcription regulatory programs for a robust induction of cell fate determinants during early brain development.
Topics & Concepts
NeurogenesisNeuroscienceCortical neuronsBiologyGenetics and Neurodevelopmental DisordersCongenital heart defects researchMicrotubule and mitosis dynamics