<i>ESRG</i> is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway
Shasha Li, Hui Liu, Weidong Liu, Ning Shi, Ming Zhao, Siyi Wanggou, Weiren Luo, Lei Wang, Bin Zhu, Xiang Zuo, Wen Xie, Cong Zhao, Yao Zhou, Longlong Luo, Xiang Gao, Xingjun Jiang, Caiping Ren
Abstract
, as a novel target of OCT4, plays an essential role in maintaining the cell survival and self-renewal/pluripotency of hPSCs in collaboration with MCM2 to suppress p53 signaling. These findings provide critical insights into the mechanisms underlying the maintenance of self-renewal and pluripotency in hPSCs by lncRNAs.
Topics & Concepts
Induced pluripotent stem cellCell biologyBiologyGene knockdownTranscription factorCell fate determinationEmbryonic stem cellGeneticsApoptosisGenePluripotent Stem Cells ResearchCRISPR and Genetic EngineeringRNA Interference and Gene Delivery