Neuroprotective effects of a new triterpenoid from edible mushroom on oxidative stress and apoptosis through the BDNF/TrkB/ERK/CREB and Nrf2 signaling pathway <i>in vitro</i> and <i>in vivo</i>
Rong-Wei Kou, Bing Xia, Rui Han, Zhiqing Li, Jun-Ren Yang, Xia Yin, Yuwan Gao, Jin‐Ming Gao
Abstract
the Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway. Hence, this mushroom could be a potential dietary supplement to ameliorate neurodegenerative diseases.
Topics & Concepts
NeuroprotectionOxidative stressCREBMAPK/ERK pathwayChemistryReactive oxygen speciesSH-SY5YPharmacologyApoptosisBiochemistrySignal transductionBiologyTranscription factorCell cultureNeuroblastomaGeneGeneticsMedicinal Plants and Bioactive CompoundsTryptophan and brain disordersFungal Biology and Applications