Overcoming Nanoparticle-Mediated Complement Activation by Surface PEG Pairing
Martina Pannuzzo, Sara Esposito, Linping Wu, Jaehong Key, Santosh Aryal, Christian Celia, Luisa di Marzio, S. Moein Moghimi, Paolo Decuzzi
Abstract
molecules to become more stretched and assume an extended, random coil configuration. As supported by coarse-grained molecular dynamics simulations, these conformational attributes minimize statistical protein binding/intercalation, thereby affecting sequential dynamic processes in complement convertase assembly. Furthermore, PEG pairing has no additional effect on nanoparticle longevity in the blood and macrophage uptake. PEG pairing significantly overcomes nanoparticle-mediated complement activation without the need for surface functionalization with complement inhibitors.
Topics & Concepts
Complement systemNanoparticleBiophysicsChemistryC3-convertasePairingPEG ratioClassical complement pathwayInnate immune systemAlternative complement pathwayNanotechnologyMaterials scienceBiochemistryBiologyImmunologyImmune systemSuperconductivityFinanceReceptorEconomicsPhysicsQuantum mechanicsComplement system in diseasesImmune Cell Function and InteractionBlood groups and transfusion