Interconnections of Pseudomonas aeruginosa Quorum-Sensing Systems in Intestinal Permeability and Inflammation
Vijay Kumar Singh, Marianna Almpani, Kelsey M. Wheeler, Laurence G. Rahme
Abstract
Pseudomonas aeruginosa is a common multidrug-resistant bacterial pathogen that seriously threatens critically ill and immunocompromised patients. Intestinal colonization by this pathogen is associated with elevated mortality rates. Disrupting bacterial communication is a desirable anti-infective approach since these systems coordinate multiple acute and chronic virulence functions in P. aeruginosa. Here, we investigate the role of each of the three major communication systems in the host intestinal functions. This work reveals that P. aeruginosa influences intestinal inflammation and permeability through distinct mechanisms.
Topics & Concepts
Pseudomonas aeruginosaQuorum sensingPathogenMicrobiologyColonizationOpportunistic pathogenBiologyInflammationBacteriaMedicineImmunologyBiofilmGeneticsBacterial biofilms and quorum sensingInhalation and Respiratory Drug DeliveryBarrier Structure and Function Studies