Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs
Hui Wang, Andrea Adamcakova‐Dodd, Susanne Flor, Laura E Gosse, Violet E. Klenov, Jeffrey M. Stolwijk, Hans‐Joachim Lehmler, Keri C. Hornbuckle, Gabriele Ludewig, Larry W. Robertson, Peter S. Thorne
Abstract
PCB levels in tissues. Neurobehavioral testing demonstrated a modest effect on spatial learning and memory in SAM-exposed rats. PCB exposure induced oxidative stress in the liver and lungs, affected the maturational stages of hematopoietic stem cells, reduced telomerase activity in bone marrow cells, and altered the gut microbiota. This is the first study to emulate PCB exposures in a school and comprehensively evaluate toxicity.
Topics & Concepts
CongenerToxicityInhalationInhalation exposureEnvironmental chemistryToxicologyChemistryMedicineBiologyAnesthesiaOrganic chemistryToxic Organic Pollutants ImpactAir Quality and Health ImpactsCarcinogens and Genotoxicity Assessment