Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
Zhichao Wu, Karen Dazelle, Zied Abdullaev, Hye‐Jung Chung, Sonika Dahiya, Matthew Wood, Jeong Han Lee, Calixto‐Hope G. Lucas, Qinwen Mao, Lorraina Robinson, Igor A. Fernandes, Matthew McCord, Peter Pytel, Kyle Conway, Rebecca A. Yoda, Jennifer Eschbacher, Ossama Maher, Martin Hasselblatt, Bret C. Mobley, Jack Raisanen, Kimmo J. Hatanpaa, Joshua T. Byers, Norman L. Lehman, Patrick J. Cimino, Drew Pratt, Martha Quezado, Kenneth Aldape
Abstract
Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characteristics. Here, we describe 39 new cases and combine these with 37 previously published cases for a cohort of 76 PTPR's, all confirmed by methylation profiling. As previously reported, two main methylation groups were identified (PTPR-A and PTPR-B). In our analysis we extended the subtyping into three subtypes: PTPR-A, PTPR-B1 and PTPR-B2 supported by DNA methylation profile and genomic copy number variations. Frequent loss of chromosome 3 or 14 was found in PTPR-B1 tumors but not in PTPR-B2. Examination of clinical outcome showed that nearly half (14/30, 47%) of examined patients experienced tumor progression with significant difference among the subtypes (p value = 0.046). Our analysis extends the understanding of this uncommon but distinct neuroepithelial tumor by describing its molecular heterogeneity and clinical outcomes, including its tendency towards tumor recurrence.