Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumor immunity
Máté Manczinger, Balázs Koncz, Gergő Mihály Balogh, Benjamin Tamás Papp, Leó Asztalos, Lajos Kemény, Balázs Papp, Csaba Pál
Topics & Concepts
Human leukocyte antigenBiologyImmunogenicityImmune systemRepertoireImmunologyAlleleImmunityGeneAntigenGeneticsAcousticsPhysicsImmunotherapy and Immune Responsesvaccines and immunoinformatics approachesT-cell and B-cell Immunology