pH-Sensitive branched β-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity
Shin Yanagihara, Nozomi Kasho, Koichi Sasaki, Naoto Shironaka, Yukiya Kitayama, Eiji Yuba, Atsushi Harada
Abstract
T cells, and polarized macrophages to the antitumor M1-phenotype within the tumor microenvironment. Therefore, pH-sensitive Aquaβ derivatives can be promising materials for liposomal antigen delivery systems to induce antitumor immune responses efficiently.
Topics & Concepts
LiposomeIn vitroImmune systemGlucanIn vivoAntigenImmunityChemistryCell biologyBiochemistryImmunologyBiologyBiotechnologyImmunotherapy and Immune ResponsesRNA Interference and Gene DeliveryAntimicrobial Peptides and Activities