Clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis
Hao Gong, Kaiming Li, Rui Xie, Guoqing Du, Linghui Li, Shang-Quan Wang, Jing Yin, Jinyu Gu, Ping Wang, Ming Chen, Xiao-Zhou Hou
Abstract
Abstract Objective: Knee osteoarthritis (KOA) is the most common degenerative disease of the joints caused by articular cartilage injury, degeneration of joint edges and hyperplasia of subchondral bone. The purpose of this study is to investigate the efficacy and safety of clinical therapy of platelet-rich plasma vs hyaluronic acid injections in patients with KOA. Methods: We systematically investigated Pubmed, Embase, and the Cochrane Library for all related articles published through May 2020. Any study was included that compared the effect of platelet-rich plasma (PRP) and hyaluronic acid (HA) in patients with KOA. The search terms included “platelet-rich plasma,” “PRP,” “hyaluronic acid,” “HA,” “knee,” “osteoarthritis,” “arthritis,” “KOA”. Review Manager 5.3 was used to analyze and calculate data regarding these outcome indicators. Results: In this study, Conclusion: In improving knee function and quality of life, PRP showed superiority over HA in long-term follow-up from well-designed double-blind trials, but a large number of high-quality multi-center studies are still needed to provide more sufficient evidence.