Synthesis and Antibacterial Activity of 4-Oxo-2-thienylaminobut-2-enoic Acids
I. A. Gorbunova, V. M. Shadrin, Н. А. Пулина, В. В. Новикова, С. С. Дубровина, D. A. Shipilovskikh, Sergei A. Shipilovskikh
Abstract
Abstract The hydrolysis of substituted 3-(3-cyanothiophen-2-yl)imino-3H-furan-2-ones was studied. It was found that the reaction proceeds with the opening of the furan ring and the formation of the corresponding 4-oxo-2-(3-cyanothiophen-2-yl)aminobut-2-enoic acids. The antibacterial activity of the obtained compounds against Staphylococcus aureus, Escherichia coli and Candida albicans was studied.
Topics & Concepts
ChemistryCandida albicansFuranAntibacterial activityStaphylococcus aureusHydrolysisEscherichia coliRing (chemistry)AntifungalStereochemistryOrganic chemistryBacteriaMicrobiologyBiochemistryGeneGeneticsBiologyChemical synthesis and pharmacological studiesSynthesis of heterocyclic compoundsSynthesis and Reactions of Organic Compounds