Development of novel <i>N</i>-(6-methanesulfonyl-benzothiazol-2-yl)-3-(4-substituted-piperazin-1-yl)-propionamides with cholinesterase inhibition, anti-β-amyloid aggregation, neuroprotection and cognition enhancing properties for the therapy of Alzheimer's disease
Chandra Bhushan Mishra, S. Shalini, Siddharth Gusain, Amresh Prakash, Jyoti Kumari, Shikha Kumari, Anita Yadav, Andrew M. Lynn, Manisha Tiwari
Abstract
neurotoxicity in SHSY-5Y cells. Notably, compound 12 significantly improved cognition and spatial memory against scopolamine-induced memory deficit in a mouse model. Hence, our results corroborate the multifunctional nature of novel hybrid molecule 12 against AD and it may be a suitable lead for further development as an effective therapeutic agent for therapy in the future.
Topics & Concepts
NeuroprotectionCholinesteraseAmyloid (mycology)ChemistryAmyloid βPharmacologyMedicineInternal medicineDiseaseInorganic chemistryCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer's disease research and treatments