Resolving SARS-CoV-2 CD4+ T cell specificity via reverse epitope discovery
Mikhail V. Pogorelyy, Elisa Rosati, Anastasia A. Minervina, Robert C. Mettelman, Alexander Scheffold, André Franke, Petra Bächer, Paul G. Thomas
Abstract
T cell responses to SARS-CoV-2 and demonstrate the utility of the reverse epitope discovery approach.
Topics & Concepts
EpitopeVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)Sars virus2019-20 coronavirus outbreakSevere acute respiratory syndromeBiologyComputational biologyMedicineAntigenImmunologyInfectious disease (medical specialty)DiseaseOutbreakPathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesCAR-T cell therapy research