Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1
Sarah M. Davis, Vignesh Hariharan, Agnes S. Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova
Abstract
-targeting siRNAs. The optimization strategy here provides a framework for the chemical optimization of siRNAs for PE as well as other targets and clinical indications.
Topics & Concepts
Gene silencingSmall interfering RNAPotencyRNA interferencePreeclampsiaNucleaseDuplex (building)Tyrosine kinaseFetusConjugateCancer researchPharmacologyBiologyChemistryMedicineImmunologyPregnancyCell biologyBiochemistryTransfectionRNAEnzymeGeneSignal transductionGeneticsIn vitroDNAMathematical analysisMathematicsMicroRNA in disease regulationPregnancy and preeclampsia studiesReproductive System and Pregnancy