Akkermansia muciniphila Prevents Fatty Liver Disease, Decreases Serum Triglycerides, and Maintains Gut Homeostasis
Sejeong Kim, Yewon Lee, Yujin Kim, Yeongeun Seo, Heeyoung Lee, Jimyeong Ha, Jeeyeon Lee, Yukyung Choi, Hyemin Oh, Yohan Yoon
Abstract
This study investigated the effect of Akkermansia muciniphila on fatty liver disease. Although some research about the effects of A. muciniphila on host health has been published, study of the relationship between A. muciniphila administration and fatty liver, as well as changes in the gut microbiota, has not been conducted. In this study, we demonstrated that A. muciniphila prevented fatty liver disease by regulation of the expression of genes that regulate fat synthesis and inflammation in the liver.
Topics & Concepts
Akkermansia muciniphilaFatty liverBiologyAkkermansiaHomeostasisGut floraInternal medicineDiseaseEndocrinologyMicrobiologyMedicineImmunologyBiochemistryLactobacillusFermentationGut microbiota and healthLiver Disease Diagnosis and TreatmentDiet and metabolism studies