Iron‐Catalyzed Alkene Trifluoromethylation in Tandem with Phenol Dearomatizing Spirocyclization: Regioselective Construction of Trifluoromethylated Spirocarbocycles
Yilin Zhao, Xue Wang, Ru Yao, Chengwen Li, Zelin Xu, Liming Zhang, Guifang Han, Jingli Hou, Yangping Liu, Yuguang Song
Abstract
Abstract In the presence of Fe(III) complex and Bipy ligand, CF 3 ‐containing spirocarbocycles were conveniently obtained in 20–99% yields with high regioselectivity through Iron‐catalyzed trifluoromethylation of unactivated alkenes coupled with phenol dearomatizing spirocyclization. magnified image
Topics & Concepts
RegioselectivityChemistryTrifluoromethylationAlkenePhenolCatalysisTandemLigand (biochemistry)Combinatorial chemistryOrganic chemistryMedicinal chemistryTrifluoromethylReceptorBiochemistryAlkylComposite materialMaterials scienceFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsInorganic Fluorides and Related Compounds