Advances in methods for atomic resolution macromolecular structure determination
Michael C. Thompson, Todd O. Yeates, José A. Rodríguez
Abstract
Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes.
Topics & Concepts
Open peer reviewPlant biologyResolution (logic)Computational biologyPhysiologyMacromoleculeNeuroscienceNanotechnologyBiologyMedicineBiophysicsComputer scienceMaterials scienceArtificial intelligenceBiochemistryBotanyEnzyme Structure and FunctionAdvanced Electron Microscopy Techniques and ApplicationsMass Spectrometry Techniques and Applications