Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer
John R. Christin, Chunhui Wang, Chi-Yeh Chung, Yu Liu, Christopher Dravis, Wei Tang, Maja H. Oktay, Geoffrey M. Wahl, Wenjun Guo
Abstract
LSPC determinant SOX9 acts as a lineage plasticity driver for BLBC progression.
Topics & Concepts
SOX9ReprogrammingBiologyProgenitor cellTranscription factorCancer researchProgenitorStem cellDownregulation and upregulationCell biologyCellGeneticsGeneCancer Cells and MetastasisBreast Cancer Treatment StudiesImmunotherapy and Immune Responses