Electrochemical reaction of indole-tethered alkynes enabling stereoselective synthesis of iodovinyl spiroindolenine-cyclopentanes
Jingrui He, Xinrui Zhou, Haibo Mei, Ata Makarem, Ramin Javahershenas, Vadim A. Soloshonok, Jianlin Han
Abstract
An electrochemical iodination/spirocyclization reaction of 3-alkynyl indoles with n -Bu 4 NI as coupling partner and electrolyte is reported, which affords iodovinyl spiroindolenine-cyclopentanes in excellent yields and high E -stereoselectivities.
Topics & Concepts
CyclopentanesStereoselectivityElectrochemistryIndole testChemistryCombinatorial chemistryElectrolyteHalogenationOrganic chemistryMedicinal chemistryCatalysisElectrodePhysical chemistryOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions