Alterations in gastrointestinal motility assessed by high-resolution antroduodenal manometry in patients with severe disorders of gut-brain interaction
Heithem Soliman, Fabien Wuestenberghs, Charlotte Desprez, Anne‐Marie Leroi, Chloé Melchior, Guillaume Gourcerol
Abstract
Gastrointestinal dysmotility has been assessed poorly in disorders of gut-brain interaction (DGBI), especially with high-resolution antroduodenal manometry. Plots of DGBI patients showed lower duodenal contractions during phase II regarding amplitude, frequency, and contractile integral/sensor (CI/s) compared with healthy volunteers. A lower frequency of propagated antroduodenal contractions was also reported. Finally, antral CI/s was lower in patients with functional dyspepsia during phase III. Further studies are needed to assess the clinical significance of these alterations.
Topics & Concepts
Migrating motor complexIrritable bowel syndromeDuodenumAntrumInternal medicineGastroenterologyHigh resolution manometryMotilityMedicinePylorusIntestinal motilityMotor activityHigh resolutionStomachBiologyRefluxDiseaseGeneticsGeologyRemote sensingGastrointestinal motility and disordersInfant Health and DevelopmentDiet and metabolism studies