Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells
Kodandaramireddy Nalapareddy, Aishlin Hassan, Leesa Sampson, Yi Zheng, Hartmut Geiger
Abstract
improves crypt regeneration in aged mice. Thus, pharmacological reduction of Cdc42 activity can improve the regeneration of aged intestinal epithelium.
Topics & Concepts
CDC42Stem cellOrganoidCryptLGR5Cell biologyIntestinal epitheliumRegeneration (biology)Intestinal mucosaHomeostasisRegenerative medicineEpitheliumBiologyChemistryInternal medicineEndocrinologyMedicineSignal transductionGeneticsCancer stem cellCancer Cells and MetastasisFOXO transcription factor regulationDigestive system and related health