A Platform for the Synthesis of Diverse Phosphonyl and Thiofunctionalized Sulfoxonium Ylides
Wen‐Xuan Zou, Qiong Hu, Dan‐Ting Shen, Wen-Rong Wu, Jiaohang Wei, Zifeng Yang, Mei-Zhu Bao, Xiang Liu, Shang‐Shi Zhang
Abstract
A practical strategy for the construction of diverse phosphonyl and thiofunctionalized sulfoxonium ylides via controllable monofunctionalization of hybrid I (III) /S (VI) ylides is presented. This process allows efficient P–H insertion of I (III) /S (VI) ylides under Cu catalysis, enabling the synthesis of phosphonyl sulfoxonium ylides, whereas reaction with sulfur-containing reagents including AgSCF 3, KSC(S)OR, and KSCN under mild conditions resulted in α-trifluoromethylthiolation, dithiocarbanation, and thiocyanation of sulfoxonium ylides accordingly. Of note, wide substrate compatibility (108 examples), excellent efficiency (up to 99% yield), gram-scale experiments, and various product derivatizations highlight the synthetic utility of this protocol.