Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles
Yanchuan Li, Yu Zhang, Jinxin Wang, Dingding Xia, Miaomiao Zhuo, Lu Zhu, Dong Li, Shao‐Fei Ni, Yanping Zhu, Weidong Zhang
Abstract
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task. Herein, we report a three-component strategy to afford diverse isoxazolines and isoxazoles via [3 + 2] cycloadditions of in situ-formed nitronates and olefins/alkynes under visible-light irradiation.
Topics & Concepts
ChemistryCatalysisComponent (thermodynamics)Combinatorial chemistryIn situOrganic chemistryThermodynamicsPhysicsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions