Discovery of a novel 2-aminopyrazine-3-carboxamide as a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2) for the treatment of fibrodysplasia ossificans progressiva
Thomas Ullrich, Luca Arista, Sven Weiler, Sylvie Teixeira‐Fouchard, Valérie Broennimann, Nikolaus Stiefl, Victoria Head, Ina Krämer, Sabine Guth
Topics & Concepts
Fibrodysplasia ossificans progressivaChemistryADMEActivin receptorKinaseIn vitroPharmacologyReceptorHeterotopic ossificationBiochemistryMedicineAnatomyHeterotopic Ossification and Related ConditionsMedical Imaging and Pathology StudiesParathyroid Disorders and Treatments