eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification
Qianying Ouyang, Jiajia Cui, Yang Wang, Ke Liu, Yan Zhan, Wei Zhuo, Juan Chen, Hong-Hao Zhou, Chen‐Hui Luo, Jianming Xia, Lian‐Sheng Wang, Chengxian Guo, Jianting Zhang, Zhao-Qian Liu, Ji‐Ye Yin
Abstract
A modification of mRNAs. These findings unveil a novel mechanism underlying sepsis, implicating the pivotal role of B cells in this complex disease process regulated by eIF3a. Furthermore, eIF3a may be used to develop a potential strategy for treating sepsis.
Topics & Concepts
Function (biology)ImmunitySepsisImmunologyBiologyCell biologyChemistryImmune systemRNA modifications and cancerPeptidase Inhibition and AnalysisRNA Interference and Gene Delivery