A non-invasive method for concurrent detection of early-stage women-specific cancers
Ankur Gupta, Ganga Sagar, Zaved Siddiqui, Kanury V. S. Rao, Sujata Nayak, Najmuddin Saquib, Rajat Anand
Abstract
We integrated untargeted serum metabolomics using high-resolution mass spectrometry with data analysis using machine learning algorithms to accurately detect early stages of the women specific cancers of breast, endometrium, cervix, and ovary across diverse age-groups and ethnicities. A two-step approach was employed wherein cancer-positive samples were first identified as a group. A second multi-class algorithm then helped to distinguish between the individual cancers of the group. The approach yielded high detection sensitivity and specificity, highlighting its utility for the development of multi-cancer detection tests especially for early-stage cancers.