Long noncoding RNA NR2F1-AS1 promotes the malignancy of non-small cell lung cancer via sponging microRNA-493-5p and thereby increasing ITGB1 expression
Chan Zhang, Shangjie Wu, Rong Song, Changming Liu
Abstract
was inhibited after NR2F1-AS1 silencing. Mechanistically, NR2F1-AS1 functioned as a competing endogenous RNA for miR-493-5p and consequently increased ITGB1 expression. Rescue assays further validated that an increased output of the miR-493-5p/ITGB1 axis could neutralize the regulatory impact of NR2F1-AS1 knockdown on the malignant phenotype of NSCLC cells. In summary, the NR2F1-AS1/miR-493-5p/ITGB1 pathway initiates pro-oncogenic behavior in NSCLC tumor progression, and the NR2F1-AS1/miR-493-5p/ITGB1 axis may provide new molecular targets for anticancer therapy against NSCLC.
Topics & Concepts
microRNALong non-coding RNAMalignancyCancer researchNon-coding RNARNACellBiologyCancerLung cancerOncologyMedicineGeneGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancer