Metal-free, visible-light driven α-C(sp<sup>3</sup>)–H <i>gem</i>-difluoroallylation of glycine derivatives with trifluoromethyl alkenes and 1,3-enynes
Zi-Hang Yuan, Hong Xin, Lu Zhang, Pin Gao, Yang Xu, Xin‐Hua Duan, Li‐Na Guo
Abstract
A metal free, visible-light driven α-C(sp 3 )−H gem-difluoroallylation of glycine derivatives with CF 3 -alkenes and 1,3-enynes is presented under redox-neutral conditions with good yields and excellent functional group compatibility.
Topics & Concepts
TrifluoromethylChemistryGlycineMetalVisible spectrumRedoxMedicinal chemistryPhotochemistryStereochemistryOrganic chemistryMaterials scienceAmino acidBiochemistryAlkylOptoelectronicsFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods