Metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes: a facile access to 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles
Jiajun Zhang, Tianhui Xu, Zhengkai Chen, Xiao‐Feng Wu
Abstract
A metal-free oxidative cyclization of trifluoroacetimidohydrazides with methylhetarenes for the efficient synthesis of 3-hetaryl-5-trifluoromethyl-1,2,4-triazoles has been developed.
Topics & Concepts
TrifluoromethylChemistryOxidative phosphorylationCombinatorial chemistryMetalMedicinal chemistryOrganic chemistryBiochemistryAlkylFluorine in Organic ChemistrySynthesis and Biological EvaluationCatalytic C–H Functionalization Methods