Inhibiting microglia proliferation after spinal cord injury improves recovery in mice and nonhuman primates
Gaëtan Poulen, Emilie Aloy, Claire M. Bringuier, Nadine Mestre‐Francés, Emaëlle V.F. Artus, Maïda Cardoso, Jean‐Christophe Perez, Christophe Goze‐Bac, Hassan Boukhaddaoui, Nicolas Lonjon, Yannick N. Gerber, Florence E. Perrin
Abstract
Thus, a transient oral GW2580 treatment post-injury may provide a promising therapeutic strategy for SCI patients and may also be extended to other central nervous system disorders displaying microglia activation.
Topics & Concepts
MicrogliaSpinal cord injuryNeuroinflammationNeuroscienceSpinal cordCentral nervous systemMedicineBiologyInflammationImmunologyNeuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury ResearchImmune cells in cancer