Chemical constituents from <i>Carica papaya</i> Linn. leaves as potential cytotoxic, EGFR<sup>wt</sup> and aromatase (CYP19A) inhibitors; a study supported by molecular docking
Ashraf Hamed, Mohamed E. Abouelela, Ahmed E. El Zowalaty, Mohamed Badr, Mohamed Salaheldin A. Abdelkader
Abstract
and RMSD value of 1.69 Å. Clitorin showed the strongest interaction with aromatase (CYP19A1) for the breast cancer receptor with a posing score of -14.2074 and RMSD value of 1.56 Å. Compounds (1-3) possessed a good bioavailability score with a 0.55 value.
Topics & Concepts
CaricaAromataseChemistryDocking (animal)Cytotoxic T cellTraditional medicineBiochemistryBotanyBiologyMedicineInternal medicineIn vitroNursingCancerBreast cancerPapaya Research and Applications