Potential effects of vaccinations on the prevention of COVID-19: rationale, clinical evidence, risks, and public health considerations
Janet Sultana, Giampiero Mazzaglia, Nicoletta Luxi, Antonino Cancellieri, Annalisa Capuano, Carmen Ferrajolo, Chiara de Waure, Guido Ferlazzo, Gianluca Trifirò
Abstract
Some vaccines are being considered for their potentially beneficial role in preventing or improving the prognosis of COVID-19: influenza, pneumococcal and tuberculosis vaccines. These vaccines may have either direct effect on COVID-19 via different types of immune responses or indirect effects by reducing the burden of viral and bacterial respiratory diseases on individual patients and national healthcare system and by facilitating differential diagnoses with other viral/bacterial respiratory disease. On the other hand, a large number of candidate vaccines against SARS-CoV-2 are currently in the pipeline and undergoing phase I, II, and III clinical studies. As SARS-CoV-2 vaccines are expected to be marketed through accelerated regulatory pathways, vaccinovigilance as well as planning of a successful vaccination campaign will play a major role in protecting public health.