Homeobox B5 promotes metastasis and poor prognosis in Hepatocellular Carcinoma, via FGFR4 and CXCL1 upregulation
Qin He, Wenjie Huang, Danfei Liu, Tongyue Zhang, Yijun Wang, Xiaoyu Ji, Meng Xie, Mengyu Sun, Dean Tian, Mei Liu, Limin Xia
Abstract
HOXB5 was a potential prognostic biomarker in HCC patients and targeting this loop may provide a promising treatment strategy for the inhibition of HOXB5-mediated HCC metastasis.
Topics & Concepts
Hepatocellular carcinomaDownregulation and upregulationHomeoboxMetastasisCXCL1Cancer researchCarcinomaMedicineOncologyInternal medicineCancerBiologyTranscription factorChemokineGeneReceptorBiochemistryFibroblast Growth Factor ResearchCancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation