A colorimetric aptasensor based on a hemin/EpCAM aptamer DNAzyme for sensitive exosome detection
Jingjing Kuang, Zhibo Fu, Xuezhi Sun, Chuhui Lin, Shenglong Yang, Jiayao Xu, Min Zhang, Hongyang Zhang, Fanghong Ning, Ping Hu
Abstract
particles per mL. In addition, this method can detect exosomes in complex fetal bovine serum samples with good specificity and high sensitivity toward exosomes from breast, liver, and lung cancers with abnormal EpCAM protein expression.
Topics & Concepts
AptamerHeminDeoxyribozymeExosomeG-quadruplexChemistryDetection limitMicrovesiclesMolecular biologyBiochemistryChromatographyBiologyDNAGenemicroRNAEnzymeHemeAdvanced biosensing and bioanalysis techniquesExtracellular vesicles in diseaseRNA Interference and Gene Delivery