Excessive sodium chloride ingestion promotes inflammation and kidney fibrosis in aging mice
Anja Bernhardt, Anna Krause, Charlotte Reichardt, Hannes Steffen, Berend Isermann, Uwe Völker, Elke Hammer, Robert Geffers, Lars Philipsen, Kristin Dhjamandi, Sohail Ahmad, Sabine Brandt, Jonathan A. Lindquist, Peter R. Mertens
Abstract
Short-term experimental studies link excessive sodium ingestion with extracellular matrix accumulation and inflammatory cell recruitment, yet long-term data are scarce. Our findings with a high-salt diet over 16 mo in aging mice pinpoints to a decisive tipping point after 12 mo with tubular stress response, skewed matrisome transcriptome, and immune cell infiltration. Cell senescence was aggravated in knockout animals for cold shock Y-box binding protein (YB-1), suggesting a novel protective protein function.
Topics & Concepts
FibrosisSirius RedEndocrinologyInternal medicineInflammationKidneyChemistryBiologyMedicineChronic Kidney Disease and DiabetesDialysis and Renal Disease ManagementBirth, Development, and Health