Cobalt-Catalyzed Asymmetric 1,4-Hydroboration of Enones with HBpin
Xiang Ren, Zhan Lu
Abstract
Herein, a series of new 8-OIQ cobalt complexes were synthesized and used for cobalt-catalyzed chemo- and enantioselective 1,4-hydroboration of enones with HBpin to access chiral β,β-disubstituted ketones with good to excellent chemo- and enantioselectivties. This protocol is operationally simple and shows a broad substrate scope.
Topics & Concepts
HydroborationChemistryCobaltCatalysisEnantioselective synthesisSubstrate (aquarium)Combinatorial chemistryScope (computer science)Organic chemistryProgramming languageGeologyOceanographyComputer scienceOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis