Broadly Protective Multivalent OspA Vaccine against Lyme Borreliosis, Developed Based on Surface Shaping of the C-Terminal Fragment
Abhijeet Nayak, Wolfgang Schüler, Stefan Seidel, Iván Gómez, Andreas Meinke, Pär Comstedt, Urban Lundberg
Abstract
The development of vaccines for prevention of diseases caused by pathogenic species can encounter major obstacles if high sequence diversity is observed between individual strains. Therefore, development might be restricted either to conserved antigens, which are often rare, or to multivalent vaccines, which renders the production more costly and cumbersome. In light of this complexity, we applied a structure-based surface shaping approach for the development of a Lyme borreliosis (LB) vaccine suitable for the United States and Europe.
Topics & Concepts
BiologyLyme borreliosisAntigenLyme diseaseVirologyComputational biologyBorrelia burgdorferiImmunologyAntibodyVector-borne infectious diseasesInsect symbiosis and bacterial influencesTrypanosoma species research and implications